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KMID : 1377020200170060773
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Tissue Engineering and Regenerative Medicine
2020 Volume.17 No. 6 p.773 ~ p.785
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Studying Adipose Tissue in the Breast Tumor Microenvironment In Vitro: Progress and Opportunities
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Mertz David
Sentosa Jason
Luker Gary
Takayama Shuichi
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Abstract
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Background: The breast cancer microenvironment contains a variety of stromal cells that are widely implicated in worse patient outcomes. While many in vitro models of the breast tumor microenvironment have been published, only a small fraction of these feature adipocytes. Adipocytes are a cell type increasingly recognized to have complex functions in breast cancer.
Methods: In this review, we examine findings from recent examples of in vitro experiments modeling adipocytes within the local breast tumor microenvironment.
Results: Both two-dimensional and three-dimensional models of adipocytes in the breast tumor microenvironment are covered in this review and both have uncovered interesting phenomena related to breast tumor progression.
Conclusion: Certain aspects of breast cancer and associated adipocyte biology: extracellular matrix effects, cell-cell contact, and physiological mass transport can only be examined with a three-dimensional culture platform. Opportunities remain for innovative improvements to be made to in vitro models that further increase what is known about adipocytes during breast cancer progression.
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KEYWORD
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Adipocyte, Breast cancer, 3D culture, Microenvironment, Phenotypic assay
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